Story Published:
Jan 16, 2006 at 1:09 PM PST
Story Updated:
Aug 31, 2006 at 1:11 AM PST
PHILADELPHIA - Older people who exercise three or more
times a week are less likely to develop Alzheimer's and other types
of dementia, according to a study that adds to the evidence that
staying active can help keep the mind sharp.
Researchers found that healthy people who reported exercising
regularly had a 30 to 40 percent lower risk of dementia.
The study, published Tuesday in the Annals of Internal Medicine,
reached no conclusions about whether certain types of exercise
helped more than others, but researchers said even light activity,
such as walking, seemed to help.
"It seems like we are delaying onset," said Dr. Wayne
McCormick, a University of Washington geriatrician who was one of
the study's authors. "The surprising finding for us was that it
actually didn't take much to have this effect."
Some researchers have theorized that exercise might reduce brain
levels of amyloid, a sticky protein that clogs the brain in
Alzheimer's patients.
The study, from 1994 to 2003, followed 1,740 people ages 65 and
older who showed no signs of dementia at the outset. The
participants' health was evaluated every two years for six years.
Out of the original pool, 1,185 people were later found to be
free of dementia, 77 percent of whom reported exercising three or
more times a week; 158 people showed signs of dementia, only 67
percent of whom said they exercised that much. The rest either died
or withdrew from the study.
The study could not say if exercise helped prevented dementia
altogether, because not all of the participants were followed up to
their deaths.
The frequency of dementia was 13 per 1,000 person years for
those who said they exercised three or more times a week, compared
with 19.7 per 1,000 person years for those who reported exercising
less.
Other researchers said randomized studies - in which
participants would be randomly assigned to either exercise or
maintain their usual habits - are needed to confirm the findings.
Bill Thies, vice president for medical and scientific affairs
for the Alzheimer's Association, said a randomized trial with more
people could help answer questions such as what types of exercise
might help more than others.
"You would have to start with a group that had roughly common
habits, and change those habits in one group and not in the
other," Thies said.