I've spoken with Metro and they told me that all of their regular bus routes will run as usual today (even though it's a holiday). As for the Seahawks bus schedule, it seems the pre-game schedule will be different from the park and ride lots.

Here is what it says on Metro's web page:

Monday, November 12 San Francisco 49ers game, there will be no pre-game service; instead, use regularly scheduled transit service. After the game there will be post-game P&R Shuttle service back to the same five park-and-ride lots from the same locations as during the regular season.

For park and ride location maps along with regular schedules go to this link:
http://transit.metrokc.gov/up/spclevent/seahawks-service.html

I hope this helps you. Have a great time at the game tonight and GO HAWKS!

Cheers,
Jenni